Book The Best Hotels in Upstate South Carolina, SC for 2026 from CA $107 - Fully Refundable Options

A bench, a bicycle, and a lake surrounded by trees.

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Go beyond your typical stay in Upstate South Carolina

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Our top choices for Upstate South Carolina hotels

A modern lobby with a reception desk, seating area, and a television screen.

A hotel room with two beds, a desk with a lamp, a chair, a patterned rug, and a large window.

A hotel with a covered entrance, brick exterior, and a sign indicating it is a Best Western hotel.

A swimming pool with lounge chairs and tables, surrounded by brick buildings and a covered seating area.

1. Best Western Spartanburg I-26

Spartanburg

Santhosh

CA $131

CA $145 total

includes taxes & fees

Oct 11 - Oct 12

An outdoor seating area with sofas, a fire pit, and string lights.

A self-service kiosk with a variety of snacks and beverages, a microwave, and a refrigerated display.

A modern lounge area with seating arrangements, a large window offering a view of the outdoors, and contemporary lighting fixtures.

A modern interior with hanging chairs, tables, and a view of the parking lot.

2. Tru by Hilton Spartanburg

Spartanburg

Anthony

CA $150

CA $167 total

includes taxes & fees

Oct 25 - Oct 26

A modern hotel lobby with a long reception desk, bar area with stools, seating with patterned cushions, and a large window offering a view of greenery.

An indoor swimming pool with clear water, a blue border, and a lifeguard station. There are lounge chairs and a covered seating area.

A hotel room with a kitchenette, two beds, a red sofa, and a dining area.

A Holiday Inn Express hotel with a covered entrance, brick facade, and large windows.

3. Holiday Inn Express I-26 & Us 29 At Westgate Mall by IHG

Spartanburg

Michael

CA $146

CA $162 total

includes taxes & fees

Oct 25 - Oct 26

A modern living room with a fireplace, a flat-screen TV, and a dining area with chairs and a table.

A modern kitchen with a central island, bar stools, and pendant lighting.

A reception area with a wooden reception desk, a refrigerator stocked with beverages, and shelves with snacks.

A hotel room with a bed, a desk, a chair, a sofa, and a TV.

4. Fairfield Inn & Suites by Marriott Greenville Spartanburg/Duncan

Duncan

Joseph

CA $168

CA $189 total

includes taxes & fees

Sep 27 - Sep 28

A multi-level hotel lobby with seating areas, a fireplace, and a staircase.

A spacious lobby with a high ceiling, modern furniture, and large windows offering views of the outdoors.

A modern coffee bar with a glass display case, seating area with round tables and chairs, and a wooden ceiling.

A modern hotel building with a large glass facade, a covered entrance, and a sign reading "Four Points by Sheraton".

5. Four Points by Sheraton Spartanburg

Spartanburg

Travis

CA $157

CA $175 total

includes taxes & fees

Oct 11 - Oct 12

A modern kitchen with a central island, equipped with a microwave, toaster, and coffee machine.

A modern lobby with blue sofas, a reception desk, and a glass coffee table.

A hotel room with a desk, office chair, sofa, and a large wall art piece.

A gym with treadmills, elliptical machines, and weight machines.

6. Comfort Suites At WestGate Mall

Spartanburg

Savannah

CA $129

CA $143 total

includes taxes & fees

Oct 18 - Oct 19

A modern lounge area with a blue sofa, a round coffee table, a patterned ottoman, and a wooden reception desk.

A modern lobby with a blue sofa, a round coffee table, and a brown armchair.

A hotel room with two beds, a desk, a TV, and a patterned carpet.

A vending area with various snack and drink options, including chips, sodas, and bottled water.

7. Fairfield Inn & Suites by Marriott Greenville Simpsonville

Simpsonville

Simone

CA $119

CA $131 total

includes taxes & fees

Sep 27 - Sep 28

A modern interior with a fireplace, seating, and a wooden wall.

A hotel room with a flat-screen TV, a desk with a chair, a bed, and framed pictures on the wall.

A reception desk with a 'Welcome to Hampton' sign and a cityscape photograph.

A modern interior with seating areas, tables, a flat-screen TV, and a fireplace.

8. Hampton Inn & Suites Greenville/Spartanburg I-85, SC

Duncan

Kathy

CA $135

CA $150 total

includes taxes & fees

Oct 12 - Oct 13

A modern restaurant interior with round tables and chairs, a kitchen area, and large windows offering a view of parked cars outside.

A pool area with lounge chairs and a sign for Best Western Plus.

A reception area with a stone counter, a laptop, and a sign indicating a Chairman's Award.

A modern kitchen with a central island, three bar stools, pendant lighting, and a decorative flower arrangement.

9. Best Western Plus Greenville I-385 Inn & Suites

Greenville

Ryan

CA $107

CA $118 total

includes taxes & fees

Oct 18 - Oct 19

A modern building with a glass facade and a brick base, featuring a prominent entrance with a flag.

A modern living room with a fireplace, seating area, and a kitchen in the background.

A swimming pool with lounge chairs and a no diving sign.

A multi-story hotel with a central courtyard, a pool, and a parking area.

10. Comfort Suites Greenville Airport

Greenville

Ryan

CA $131

CA $149 total

includes taxes & fees

Oct 18 - Oct 19

A modern outdoor seating area with a blue sofa, white armchairs, and a black fire pit.

11. stayAPT Suites Greenville Greer BMW

Greer

Robert

CA $168

CA $190 total

includes taxes & fees

Sep 28 - Sep 29

A modern restaurant with a brick wall, wooden ceiling beams, and a central seating area with tables and chairs.

A reception desk with a 'Welcome to the Palmetto State' sign, a 'Local Snacks' section, and a 'Hilton Honors' sign.

An outdoor patio with a fire pit, seating area, and a TV.

An outdoor pool area with seating and umbrellas.

12. Hampton Inn Greer Greenville, SC

Greer

Teresa

CA $204

CA $222 total

includes taxes & fees

Sep 27 - Sep 28

A hotel room with a bed, a blue sofa, a wooden coffee table, a desk with a chair, and a framed abstract painting on the wall.

A food service counter with a sign that reads "EXPRESS START".

A hotel room with a blue sofa, a wooden coffee table, a bed with white linens, a desk with a chair, and a large window.

A large indoor swimming pool with a diving board, multiple doors, and seating areas.

13. Holiday Inn Express Hotel & Suites Spartanburg-North by IHG

Spartanburg

Michael

CA $140

CA $155 total

includes taxes & fees

Oct 4 - Oct 5

A modern kitchen with a large wooden table and brown leather chairs, a microwave, and a coffee machine.

A reception area with a modern design, featuring a reception desk, seating area, and a view through the glass doors.

A hotel room with two beds, a wooden headboard, a nightstand, a lamp, and a window with a view.

A compact kitchen with white cabinets, a microwave, a sink, and a flat-screen TV.

14. Extended Stay America Premier Suites - Greenville - Spartanburg - I-85

Duncan

Denise

CA $113

CA $125 total

includes taxes & fees

Oct 1 - Oct 2

A hotel room with two beds, green walls, and large black-and-white cityscape posters.

A hotel with a Super 8 sign, a swimming pool, and a covered patio area.

A modern interior with a staircase, a large wooden cabinet, and a glass door.

15. Super 8 by Wyndham Greer/Spartanburg Area

Greer

Tom Frank Frith

CA $95

CA $107 total

includes taxes & fees

Oct 1 - Oct 2

A modern living room with a fireplace, two sofas, and a coffee table.

A hotel room with two beds, a desk, a TV, and a window with curtains.

A modern gym with various exercise equipment, motivational wall graphics, and a large window offering a view of the outdoors.

A hotel lobby with multiple seating areas, a reception desk, and a fireplace.

16. Best Western Spartanburg Northwest

Spartanburg

Darius

CA $137

CA $155 total

includes taxes & fees

Oct 11 - Oct 12

A hotel room with a sofa, a small round table, a bed with two pillows, a nightstand, a lamp, a TV, and a curtain.

A reception area with a mosaic-tiled counter, multiple pendant lights, and a laptop on the counter.

A modern living room with a stone wall, a flat-screen TV, a fireplace, and large windows with a view of the street.

17. Comfort Suites Simpsonville - Greenville

Simpsonville

Lesa

CA $136

CA $150 total

includes taxes & fees

Oct 11 - Oct 12

A large indoor swimming pool with clear water, surrounded by lounge chairs and tables, and equipped with safety signage.

A modern hotel with a well-maintained lawn, brick pathway, and a row of white flowers.

A modern hotel lobby with a large TV, comfortable seating, and a view of the outdoors.

18. Hampton Inn & Suites Spartanburg-I-26-Westgate Mall

Spartanburg

CA $169

CA $188 total

includes taxes & fees

Oct 25 - Oct 26

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

An outdoor seating area with string lights, tables, and chairs at the Hilton Garden Inn.

A hotel entrance with a covered walkway, a landscaped area with trees, and a well-lit building facade.

A spacious lobby with a bar area, seating, and large windows.

19. Hilton Garden Inn Spartanburg

Spartanburg

Yuliya

CA $187

CA $207 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with a bed, a television, a mini-fridge, a microwave, a coffee maker, a chair, and a window with curtains.

A hotel with a parking lot, multiple entry points, and a clear sky.

A neatly made bed with white linens, a dark headboard, two bedside lamps, a chair, and a nightstand with a phone.

A modern dining area with multiple tables and chairs, a juice dispenser, and large windows providing natural light.

20. Comfort Inn & Suites Greer - Greenville

Greer

Leslie

CA $136

CA $152 total

includes taxes & fees

Oct 4 - Oct 5

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Vacation Rentals in Upstate South Carolina

Aparthotel

An outdoor patio with a stone barbecue grill and white Adirondack chairs.

A reception desk with a blue wall, a white counter, and dark cabinets. There is a vase with white flowers on the counter.

stayAPT Suites Greenville-Haywood Mall

Greenville

"I was there for work and I was close to everything"

Aparthotel

A modern living room with a flat-screen TV, a dining area with a round table and chairs, a kitchen with dark cabinets and a refrigerator, and a sofa with a patterned pillow.

An outdoor patio area with wicker furniture, a fireplace, and a ceiling fan.

A spacious living area with a ceiling fan, a flat-screen TV, and comfortable seating.

A modern kitchen with a coffee bar, wooden wall, and three orange bar stools.

Landing Apartments - Lyman

Lyman

"Great room that was nice and clean. Smooth check-in."

Cabin

A spacious porch with wooden flooring, a dining area with a table and chairs, and a view of the surrounding landscape.

A swimming pool with lounge chairs and a covered area with tables and chairs.

A modern bedroom with a large bed, a ceiling fan, and a view of the outdoors through a window.

Carolina Camp Cedar

Pickens

"The cottage was clean, staff was so friendly, our stay was quiet and peaceful… it was perfect! Definitely planning to stay there again!"

Cottage

A living room with a sofa, coffee table, and a dining area with chairs and a table.

A living room with a fireplace, a round wooden table with chairs, a sofa, and a television.

A covered porch with wicker furniture, a round table with a bowl and a cup, and a view of a lush garden.

A modern kitchen with white cabinets, stainless steel appliances, and a patterned rug.

1 Mi to Downtown Greer: Family Home w/ Gazebo!

Greer

"Very cute home close to everything. Super clean and spacious. Well furnished."

Cabin

A cabin in a forest with a small deck and outdoor seating area.

A wooden interior with a table, chair, and a hanging lantern.

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Me and my family had a great time"

Apartment

A modern living room with a sofa, a coffee table, a TV, and a balcony with a view of buildings.

A bedroom with a bed, bedside tables, a ceiling fan, and two windows with blinds.

A modern kitchen with granite countertops, double sinks, and a built-in dishwasher.

A modern kitchen with white cabinets, a stainless steel refrigerator, and a bar area with white stools.

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Excellent location for our trip. Very clean, had everything we needed."

Mobile Home

A wooden dining table with green placemats, surrounded by chairs, in a cabin with large windows and wooden walls.

A rustic cabin with a porch, wooden steps, and a picnic table.

A cozy cabin interior with a wooden interior, a sofa, a television on a wooden stand, and a sign on the wall.

A wooden interior with a loft bed, a green chair, a wooden table, and a map on the wall.

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Cottage

A covered patio with outdoor seating, a view of a parking lot and distant landscape.

A single-story house with a covered porch, a small garden, and a sign indicating it is a rental property.

A spacious living area with a dining table, a leather sofa, and a spiral staircase.

A modern kitchen with white cabinets, stainless steel appliances, and a granite countertop.

Stunning Lakefront Retreat w/ Dock Access!

Greenwood

Cottage

A covered porch with wooden railings and a table with chairs.

A cabin with a wooden deck, a gravel driveway, and a forested backdrop.

A two-story building with a covered porch, stone foundation, and a gravel driveway.

A cozy living room with a sectional sofa, a wooden chair, a coffee table, and a red and black patterned rug.

9 Mi to Devils Fork State Park: Getaway w/ Porch!

Tamassee

"Fall weekend getaway and this was perfect location. Loved the back porch for coffee and views of the sun through all the colorful leaves. Felt like we were away from it all but just a short drive to restaurants, stores, lakes and parks!!!"

Cottage

A spacious living room with a large sofa, a kitchen area with a bar, and a view of the outdoors through the windows.

A cozy living room with a flat-screen TV, wooden ceiling, a sofa, and a dining area with a table and chairs.

A kitchen with a wooden countertop, white chairs, and a dining table. There is a mirror on the wall and a window with blinds.

A modern kitchen with a wooden ceiling, a bar stool, a stove, and a sink.

Waterfront Cabin w/ Private Dock on Lake Hartwell!

Townville

"We booked last minute for Clemson parents weekend. It worked out fine, it is really in the middle of no where. There are no outlets in the bathroom you have to use the kitchen mirror and outlets to get ready. There was a coffee machine but no coffee. It was very clean. The deck needs some work."

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.

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A pedestrian bridge with colorful lights, surrounded by trees and a distant building.

Falls Park on the Reedy

9.6/10 (2,661 reviews)

Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.

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Bon Secours Wellness Arena

8.6/10 (1,219 reviews)

Catch an event at Bon Secours Wellness Arena during your trip to Greenville. Stroll along the riverfront or experience the great live music in this family-friendly area.

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Memorial Stadium

9.6/10 (410 reviews)

Catch an event at Memorial Stadium during your trip to Clemson. Experience the area's theater scene or attend a football game.

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Greenville Convention Center

8.4/10 (571 reviews)

Learn about the events happening at Greenville Convention Center during your trip to Greenville. Attend a sporting event or visit the shops in this family-friendly area.

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BMW Performance Center

9.0/10 (90 reviews)

You can spend an afternoon browsing the exhibits at BMW Performance Center during your travels in Greer. While in this family-friendly area, you can savor the charming coffeehouses.

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Haywood Mall

8.8/10 (1,681 reviews)

During your trip to Greenville, you can browse for the perfect souvenirs at Haywood Mall. Experience the great live music or attend a sporting event in this family-friendly area.

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Learn more about Upstate South Carolina

Venture to sights like Heritage Park and CCNB Amphitheatre as you discover Upstate South Carolina.

See all hotels in Upstate South Carolina

A multi-tiered waterfall cascading over rocks in a forested area.

Top Upstate South Carolina Hotel Reviews

Embassy Suites by Hilton Greenville Downtown Riverplace

10/10 Excellent

"Easy check in and check out. Friendly staff and great Breakfast."

Mint House Greenville Downtown by Kasa

10/10 Excellent

"Great place to stay!would stay again!"

Best Western Plus Greenville I-385 Inn & Suites

10/10 Excellent

"Stephanie at the front desk was very nice and helpful. She was very helpful in helping us find a place to eat. The room was very clean and comfortable. We enjoyed our short stay."

Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

10/10 Excellent

"This place is very homy and the manager was so sweet. I loved all decoration(lots of life quotes). I wish they are pet friendly as we traveled with our dog, but no complain! our room was on the 3rd floor and the ice machine on the hallway was not working, but we enjoyed stayed. Lots of places to eat around. There are some resraurants you can walk. The bed was confortable and shower was strong enogh. I hope we have another chance to stay here. Again, Thank you very much!"

Best Western Plus Clemson Hotel & Conference Center

10/10 Excellent

"Great spot"

Grand Bohemian Lodge Greenville, Autograph Collection

10/10 Excellent

"Beautiful hotel with all the amenities! Large rooms and bathrooms, great coffee maker and steamer for clothes. Beautiful views outside of restaurant. Will definitely return!"

Hyatt Place Greenville/Haywood

8/10 Good

"The staff was lovely and the rooms were great nice comfortable bed. We had a really nice view from the window on the fifth floor. The only thing was they were doing renovations which I wasn’t expecting. Other than that everything was great."

More cheap stays in Upstate South Carolina

Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

1024 Woodruff Rd Greenville SC

CA $99

CA $109 total

Oct 12 - Oct 13

includes taxes & fees

8.4/10 Very good! (1,002 reviews)

Best Western Plus Greenville I-385 Inn & Suites

831 Congaree Rd Greenville SC

CA $107

CA $118 total

Oct 18 - Oct 19

includes taxes & fees

9/10 Wonderful! (1,577 reviews)

Comfort Inn Greenville - Haywood Mall

246 Congaree Road Greenville SC

CA $115

CA $130 total

Oct 18 - Oct 19

includes taxes & fees

Comfort Inn & Suites Clemson - University Area

1305 Tiger Blvd Clemson SC

CA $149

CA $165 total

Oct 18 - Oct 19

includes taxes & fees

Best Western Plus Clemson Hotel & Conference Center

1310 Tiger Blvd Clemson SC

CA $149

CA $165 total

Oct 4 - Oct 5

includes taxes & fees

8/10 Very good! (1,000 reviews)

Lakeside Lodge Clemson

13500 Clemson Blvd Seneca SC

CA $154

CA $191 total

Sep 27 - Sep 28

includes taxes & fees

Hotels in Upstate South Carolina with star rating

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Things to do in Upstate South Carolina

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Find hotels in Upstate South Carolina, SC from CA $107

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Upstate South Carolina

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Upstate South Carolina hotels

1. Best Western Spartanburg I-26

2. Tru by Hilton Spartanburg

3. Holiday Inn Express I-26 & Us 29 At Westgate Mall by IHG

4. Fairfield Inn & Suites by Marriott Greenville Spartanburg/Duncan

5. Four Points by Sheraton Spartanburg

6. Comfort Suites At WestGate Mall

7. Fairfield Inn & Suites by Marriott Greenville Simpsonville

8. Hampton Inn & Suites Greenville/Spartanburg I-85, SC

9. Best Western Plus Greenville I-385 Inn & Suites

10. Comfort Suites Greenville Airport

11. stayAPT Suites Greenville Greer BMW

12. Hampton Inn Greer Greenville, SC

13. Holiday Inn Express Hotel & Suites Spartanburg-North by IHG

14. Extended Stay America Premier Suites - Greenville - Spartanburg - I-85

15. Super 8 by Wyndham Greer/Spartanburg Area

16. Best Western Spartanburg Northwest

17. Comfort Suites Simpsonville - Greenville

18. Hampton Inn & Suites Spartanburg-I-26-Westgate Mall

19. Hilton Garden Inn Spartanburg

20. Comfort Inn & Suites Greer - Greenville

Vacation Rentals in Upstate South Carolina

stayAPT Suites Greenville-Haywood Mall

Landing Apartments - Lyman

Carolina Camp Cedar

1 Mi to Downtown Greer: Family Home w/ Gazebo!

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Mint House Greenville Downtown by Kasa

Carolina Landing RV Resort - Caravan Park

Stunning Lakefront Retreat w/ Dock Access!

9 Mi to Devils Fork State Park: Getaway w/ Porch!

Waterfront Cabin w/ Private Dock on Lake Hartwell!

Stay near popular Upstate South Carolina attractions

Clemson University

Falls Park on the Reedy

Bon Secours Wellness Arena

Memorial Stadium

Greenville Convention Center

BMW Performance Center

Haywood Mall

Learn more about Upstate South Carolina

Top Upstate South Carolina Hotel Reviews

Embassy Suites by Hilton Greenville Downtown Riverplace

Mint House Greenville Downtown by Kasa

Best Western Plus Greenville I-385 Inn & Suites

Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

Best Western Plus Clemson Hotel & Conference Center

Grand Bohemian Lodge Greenville, Autograph Collection

Hyatt Place Greenville/Haywood

More cheap stays in Upstate South Carolina

Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

Best Western Plus Greenville I-385 Inn & Suites

Comfort Inn Greenville - Haywood Mall

Comfort Inn & Suites Clemson - University Area

Best Western Plus Clemson Hotel & Conference Center

Lakeside Lodge Clemson

Hotels in Upstate South Carolina with star rating

Explore a world of travel with Expedia

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