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Our top choices for Upstate South Carolina hotels

A modern lobby with a reception desk, seating area, and a television screen.

1. Best Western Spartanburg I-26

Spartanburg

Santhosh

CA $145 total

includes taxes & fees

Nov 15 - Nov 16

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

2. Hilton Garden Inn Spartanburg

Spartanburg

Patrick

CA $159 total

includes taxes & fees

Nov 29 - Nov 30

A rooftop bar with seating, a bar area, and a view of the cityscape at dusk.

3. AC Hotel by Marriott Spartanburg

Spartanburg

James

CA $199 total

includes taxes & fees

Nov 29 - Nov 30

A modern kitchen with a central island, bar stools, and pendant lighting.

4. Hampton Inn & Suites Spartanburg-I-26-Westgate Mall

Spartanburg

Melinda

CA $167 total

includes taxes & fees

Nov 27 - Nov 28

A modern restaurant interior with round tables and chairs, a kitchen area, and large windows offering a view of parked cars outside.

5. Best Western Plus Greenville I-385 Inn & Suites

Greenville

Rubin

CA $117 total

includes taxes & fees

Dec 6 - Dec 7

A modern hotel lobby with a long reception desk, bar area with stools, seating with patterned cushions, and a large window offering a view of greenery.

6. Holiday Inn Express I-26 & Us 29 At Westgate Mall by IHG

Spartanburg

david

CA $165 total

includes taxes & fees

Dec 6 - Dec 7

A modern living room with a fireplace, seating area, and a kitchen in the background.

7. Comfort Suites Greenville Airport

Greenville

Adam

CA $142 total

includes taxes & fees

Nov 29 - Nov 30

A modern kitchen with a central island, equipped with a microwave, toaster, and coffee machine.

8. Comfort Suites At WestGate Mall

Spartanburg

Willie

CA $137 total

includes taxes & fees

Nov 29 - Nov 30

A hotel room with two beds, a bedside table, a lamp, and a window with curtains.

9. Clarion Inn

Greenville

Johnny

CA $110 total

includes taxes & fees

Nov 29 - Nov 30

A spacious lobby with a reception desk, green seating area, and multiple tables and chairs.

10. Home2 Suites by Hilton Duncan

Duncan

Luella

CA $192 total

includes taxes & fees

Nov 22 - Nov 23

A modern living room with a fireplace, two sofas, and a coffee table.

11. Best Western Spartanburg Northwest

Spartanburg

Herbert

CA $141 total

includes taxes & fees

Dec 6 - Dec 7

A multi-level hotel lobby with seating areas, a fireplace, and a staircase.

12. Four Points by Sheraton Spartanburg

Spartanburg

Marcus

CA $185 total

includes taxes & fees

Nov 15 - Nov 16

An outdoor seating area with sofas, a fire pit, and string lights.

13. Tru by Hilton Spartanburg

Spartanburg

Volodymyr

CA $166 total

includes taxes & fees

Nov 23 - Nov 24

A modern hotel room with a large bed, a desk, and a kitchenette.

14. Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

Greenville

Maclin

CA $111 total

includes taxes & fees

Nov 24 - Nov 25

A modern interior with a fireplace, seating, and a wooden accent wall.

15. Hampton Inn & Suites Greenville/Spartanburg I-85, SC

Duncan

Nilda

CA $155 total

includes taxes & fees

Dec 8 - Dec 9

An indoor swimming pool with multiple lanes, lounge chairs, and a clear view of the sky through large windows.

16. Holiday Inn Express & Suites Greenville-Spartanburg (Duncan) by IHG

Duncan

Dawn

CA $143 total

includes taxes & fees

Dec 10 - Dec 11

A modern kitchen with hanging light fixtures and bar seating.

17. DoubleTree by Hilton Greenville Woodruff Road

Greenville

Angie

CA $169 total

includes taxes & fees

Nov 29 - Nov 30

A multi-story hotel with a modern design, featuring a prominent 'La Quinta' sign, a parking lot, and a landscaped entrance area.

18. La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

Greenville

Sam

CA $150 total

includes taxes & fees

Dec 7 - Dec 8

A spacious lobby with a large beige sofa, a fireplace, and a modern chandelier.

19. Hilton Garden Inn Greenville

Greenville

Valerie

CA $156 total

includes taxes & fees

Nov 27 - Nov 28

A multi-level hotel lobby with a central atrium, multiple dining areas, and a reception desk.

20. Embassy Suites Greenville Golf Resort & Conference Center

Greenville

James

CA $156 total

includes taxes & fees

Nov 23 - Nov 24

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Compare top hotels in Upstate South Carolina

Best Western Spartanburg I-26 2.0 star property Spartanburg View	Hilton Garden Inn Spartanburg 3.0 star property Spartanburg View	AC Hotel by Marriott Spartanburg 3.5 star property Spartanburg View	Hampton Inn & Suites Spartanburg-I-26-Westgate Mall 2.5 star property Spartanburg View	Best Western Plus Greenville I-385 Inn & Suites 2.5 star property Greenville View
9.0 Wonderful 89 reviews	9.4 Exceptional 569 reviews	9.4 Exceptional 691 reviews	8.6 Excellent 1,000 reviews	9.2 Wonderful 1,617 reviews
The price is CA $131 CA $145 total includes taxes & fees Nov 15 - Nov 16	The price is CA $143 CA $159 total includes taxes & fees Nov 29 - Nov 30	The price is CA $179 CA $199 total includes taxes & fees Nov 29 - Nov 30	The price is CA $150 CA $167 total includes taxes & fees Nov 27 - Nov 28	The price is CA $106 CA $117 total includes taxes & fees Dec 6 - Dec 7
Yes, Breakfast included Yes, Pool No Spa No Pet-friendly Yes, WiFi included Yes, Parking	No Breakfast included Yes, Pool No Spa Yes, Pet-friendly Yes, WiFi included Yes, Parking	No Breakfast included Yes, Pool No Spa Yes, Pet-friendly Yes, WiFi included Yes, Parking	Yes, Breakfast included Yes, Pool No Spa Yes, Pet-friendly Yes, WiFi included Yes, Parking	Yes, Breakfast included Yes, Pool No Spa No Pet-friendly Yes, WiFi included Yes, Parking

Vacation Rentals in Upstate South Carolina

Aparthotel

stayAPT Suites Greenville-Haywood Mall

Greenville

"Great property and cozy. Safe area and close to mall and restaurants."

Apartment

A modern living room with a sofa, a coffee table, a TV, and a balcony with a view of buildings.

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Great location-we walked to soo many shops and restaurants!"

Cottage

A modern living room with a ceiling fan, a sofa, a chair, and a coffee table. There is a kitchen in the background with cabinets and a countertop.

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Perfect location for getting away in a quiet cabin!"

Mobile Home

A wooden dining table with green placemats, surrounded by chairs, in a cabin with large windows and wooden walls.

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Cottage

A living room with a sofa, a dining table, chairs, a kitchen area, and a view through large windows.

Greer Guest House < 1 Mi to Park & Downtown Area!

Greer

"Nice place en Greenville area "

Cottage

A living room with a blue sofa, a round coffee table with a vase of flowers, a patterned rug, and a chair. There are paintings on the walls and a window with curtains.

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Cottage

A living room with a sofa, coffee table, and a dining area with chairs and a table.

1 Mi to Downtown Greer: Family Home w/ Gazebo!

Greer

"Very cute home close to everything. Super clean and spacious. Well furnished."

Cottage

A spacious living room with a dining area, a leather sofa, a TV, and artwork on the walls.

Families Welcome, Fenced Yard: Inviting Greer Home

Greer

"This property is such an amazing find. Three large bedrooms, very clean and well maintained. Close to town of Greer and all amenities. Very easy check-in. Beds very comfortable. Kitchen well equipped for the week we were there."

Cottage

A round table with a white tablecloth, surrounded by chairs, set up for a meal.

Stay at Jos Taylor Retreat: 9 Mi to Greenville!

Taylors

"This rental is a time capsule that takes you back to Grandma and Grandpa's home. The owner is great to communicate with, as well as their property manager. Quaint older furniture, complete with blankets on the couches. There's all you need to cook and even a great cast-iron frying pan. I wish we had stayed here longer."

Apartment

A large house with a spacious driveway and a pond in the background.

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

Cottage

A modern kitchen with white and blue cabinets, stainless steel appliances, and a central island with bar stools.

4 Seasons of Fun! Walhalla Home w/ Spacious Yard!

Walhalla

"The house was perfect for our group for our golf trip. We had one minor issue and we were able to speak to the host and they had someone to correct it quickly so that it didn’t disrupt our trip in any way. Place was clean, peaceful, with great hosts."

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.

See properties

Learn more about Upstate South Carolina

Venture to sights like Discovery Island Water Park and Heritage Park as you discover Upstate South Carolina.

See all hotels in Upstate South Carolina

A multi-tiered waterfall cascading over rocks in a forested area.

Top Upstate South Carolina Hotel Reviews

Best Western Plus Greenville I-385 Inn & Suites

8/10 Good

"The room was clean however the noises from the outside were very annoying the ice machine was rumbling half the night. I think the room could have provided more soap and other accessories for the bathroom . Overall it was a 9 experience 👍👍"

Best Western Spartanburg I-26

10/10 Excellent

"Our room was perfect! Very clean and the bed & pillows were very comfortable! Very quiet. Breakfast was substantial. Eggs, bacon, pancakes, different types of cereal and pastries. Different juices and great selection of hot beverages. The staff was very friendly and helpful. We definitely will be back."

Comfort Suites Greenville Airport

10/10 Excellent

"Safe and convenient location right off the interstate. Front desk staff were friendly and check in was easy. Room was clean, comfortable, and spacious. Breakfast was very good, self-serve with the usual options such as egg, sausage, waffles, etc. Definitely recommend staying here to other travelers."