Title: Book The Best Hotels in Upstate South Carolina for 2026 from CA $97 - Fully Refundable Options - Expedia.ca [Upstate South Carolina Travel Guide](https://expedia.ca/Upstate-South-Carolina.dx553248635975748552)[Vacation Rentals in Upstate South Carolina](https://expedia.ca/Upstate-South-Carolina-Vacation-Rentals.d553248635975748552.Travel-Guide-VacationRentals)[Flights to Upstate South Carolina](https://expedia.ca/Cheap-Flights-To-Upstate-South-Carolina.d553248635975748552.Travel-Guide-Flights)[Things to do in Upstate South Carolina](https://expedia.ca/Things-To-Do-In-Upstate-South-Carolina.d553248635975748552.Travel-Guide-Activities)[Upstate South Carolina Car Rentals](https://expedia.ca/Car-Rentals-In-Upstate-South-Carolina.d553248635975748552.Car-Rental-Guide)[Upstate South Carolina Vacation Packages](https://expedia.ca/Upstate-South-Carolina.d553248635975748552.Destination-Travel-Guides) ![It is only a 1 mile hike to this beauty. View a video about it here: https://www.hdcarolina.com/episode/riley-moore-falls #Waterfall](https://images.trvl-media.com/place/6122927/69b8ebaa-53a3-428e-ba53-37ac2de11862.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Ryan Watts ![](https://images.trvl-media.com/place/6122927/69b8ebaa-53a3-428e-ba53-37ac2de11862.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Upstate South Carolina Spa [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-04-07&d1=2026-04-07&endDate=2026-04-09&d2=2026-04-09&amenities=SPA_ON_SITE) Pet friendly [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-04-07&d1=2026-04-07&endDate=2026-04-09&d2=2026-04-09&amenities=PETS) Pool [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-04-07&d1=2026-04-07&endDate=2026-04-09&d2=2026-04-09&amenities=POOL) Cabin [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-04-07&d1=2026-04-07&endDate=2026-04-09&d2=2026-04-09&lodging=CABIN) Hot tub [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-04-07&d1=2026-04-07&endDate=2026-04-09&d2=2026-04-09&amenities=HOT_TUB) Apart hotel [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-04-07&d1=2026-04-07&endDate=2026-04-09&d2=2026-04-09&lodging=APART_HOTEL) Family friendly [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-04-07&d1=2026-04-07&endDate=2026-04-09&d2=2026-04-09&travelerType=family_friendly) Farm [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-04-07&d1=2026-04-07&endDate=2026-04-09&d2=2026-04-09&lodging=AGRITOURISM) Apart­ment [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-04-07&d1=2026-04-07&endDate=2026-04-09&d2=2026-04-09&lodging=APARTMENT) Cottage [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-04-07&d1=2026-04-07&endDate=2026-04-09&d2=2026-04-09&lodging=COTTAGE) Condo [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-04-07&d1=2026-04-07&endDate=2026-04-09&d2=2026-04-09&lodging=CONDO) ## Check prices for these dates Tonight [Mar 24 - Mar 25](https://www.expedia.ca/Hotel-Search?regionId=553248635975748552&startDate=2026-03-24&endDate=2026-03-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 25 - Mar 26](https://www.expedia.ca/Hotel-Search?regionId=553248635975748552&startDate=2026-03-25&endDate=2026-03-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 27 - Mar 29](https://www.expedia.ca/Hotel-Search?regionId=553248635975748552&startDate=2026-03-27&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Apr 3 - Apr 5](https://www.expedia.ca/Hotel-Search?regionId=553248635975748552&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Upstate South Carolina hotels ![Premium bedding, in-room safe, individually furnished, laptop workspace](https://images.trvl-media.com/lodging/123000000/122100000/122099800/122099740/afe0f510.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin, 1 Bedroom, Courtyard View | Living area](https://images.trvl-media.com/lodging/123000000/122100000/122099800/122099740/3f2de599.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool, open 7:00 AM to 10:00 PM, pool umbrellas](https://images.trvl-media.com/lodging/123000000/122100000/122099800/122099740/b26b87ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin, 1 Bedroom, Courtyard View | Front of property](https://images.trvl-media.com/lodging/123000000/122100000/122099800/122099740/f825207a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Carolina Camp Cedar [](https://www.expedia.ca/Pickens-Hotels-Carolina-Camp-Cedar.h122099740.Hotel-Information) Pickens 10/10 Exceptional (3 reviews) "The cottage was clean, staff was so friendly, our stay was quiet and peaceful… it was perfect! Definitely planning to stay there again!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Katlynn CA $133 CA $262 total includes taxes & fees Mar 30 - Mar 31 [](https://www.expedia.ca/Pickens-Hotels-Carolina-Camp-Cedar.h122099740.Hotel-Information) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/375f69b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/f6f7c8c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/16b3def6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/eab53b27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Seneca Clemson Area US-123 [](https://www.expedia.ca/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information) Downtown 8.0/10 Very good (689 reviews) "Everting was good" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Susan CA $107 CA $126 total includes taxes & fees Apr 16 - Apr 17 [](https://www.expedia.ca/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/69000000/68980000/68975500/68975422/d93f55e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/69000000/68980000/68975500/68975422/2f127f57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/69000000/68980000/68975500/68975422/9d9a13cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/69000000/68980000/68975500/68975422/799eeb33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Greer Greenville, SC [](https://www.expedia.ca/Greer-Hotels-Hampton-Inn-Greer-Greenville.h68975422.Hotel-Information) Greer 9.6/10 Exceptional (441 reviews) "Parking garage for hotel guests, location was great, hotel was clean, staff was great. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tyler CA $191 CA $208 total includes taxes & fees Mar 27 - Mar 28 [](https://www.expedia.ca/Greer-Hotels-Hampton-Inn-Greer-Greenville.h68975422.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/c321176c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/2b6111ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, desk, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/f9325683.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/b23b9566.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Inn on the Square, an Ascend Collection Hotel [](https://www.expedia.ca/Greenwood-Hotels-Inn-On-The-Square.h1212931.Hotel-Information) Uptown Greenwood 9.2/10 Wonderful (725 reviews) "Room was very comfy and very clean. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mary CA $162 CA $180 total includes taxes & fees Apr 19 - Apr 20 [](https://www.expedia.ca/Greenwood-Hotels-Inn-On-The-Square.h1212931.Hotel-Information) ![BBQ/picnic area](https://images.trvl-media.com/lodging/1000000/110000/105600/105540/fd542db9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/110000/105600/105540/c83ed6f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/110000/105600/105540/a7c81686.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/110000/105600/105540/9b9d3bd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Travelers Rest Greenville [](https://www.expedia.ca/Travelers-Rest-Hotels-Best-Western-Travelers-Rest-Greenville.h105540.Hotel-Information) Travelers Rest 7.6/10 Good (1,000 reviews) "Everything was wonderful. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Debra CA $121 CA $133 total includes taxes & fees Mar 31 - Apr 1 [](https://www.expedia.ca/Travelers-Rest-Hotels-Best-Western-Travelers-Rest-Greenville.h105540.Hotel-Information) ![Free daily full breakfast](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/589dc000.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, desk, blackout drapes](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/39d93722.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/a9c6228a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/b9808144.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Gaffney by IHG [](https://www.expedia.ca/Gaffney-Hotels-Holiday-Inn-Express-Gaffney.h71515054.Hotel-Information) Gaffney 8.8/10 Excellent (459 reviews) "Kind staff, good breakfast, clean room, comfy bed." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer CA $144 CA $157 total includes taxes & fees Mar 27 - Mar 28 [](https://www.expedia.ca/Gaffney-Hotels-Holiday-Inn-Express-Gaffney.h71515054.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/430000/424900/424882/cd259adf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Blackout drapes, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/430000/424900/424882/5a8cea9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/430000/424900/424882/1ccff62b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/430000/424900/424882/0304ce09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Gaffney [](https://www.expedia.ca/Gaffney-Hotels-Hampton-Inn-Gaffney.h424882.Hotel-Information) Gaffney 8.8/10 Excellent (693 reviews) "Would stay again breakfast was amazing " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Theresa CA $118 CA $129 total includes taxes & fees Apr 19 - Apr 20 [](https://www.expedia.ca/Gaffney-Hotels-Hampton-Inn-Gaffney.h424882.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/66000000/65710000/65708700/65708685/0f86ef1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/66000000/65710000/65708700/65708685/6d084ccc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch plasma TV with cable channels, TV](https://images.trvl-media.com/lodging/66000000/65710000/65708700/65708685/284160fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/66000000/65710000/65708700/65708685/w3840h2558x0y0-944f5cdf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Home2 Suites by Hilton Anderson Downtown [](https://www.expedia.ca/Anderson-Hotels-Home2-Suites-By-Hilton-Anderson-Downtown.h65708685.Hotel-Information) Anderson 9.4/10 Exceptional (232 reviews) "Room was great and the staff polite and helpful " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sheila D CA $192 CA $213 total includes taxes & fees Apr 5 - Apr 6 [](https://www.expedia.ca/Anderson-Hotels-Home2-Suites-By-Hilton-Anderson-Downtown.h65708685.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/83732283.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/ac7a917f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/590fd43d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/62fa3a56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru by Hilton Seneca Clemson [](https://www.expedia.ca/Anderson-Hotels-Tru-By-Hilton-Seneca-Clemson.h34323330.Hotel-Information) Seneca 9.2/10 Wonderful (817 reviews) "The hotel was very clean staff was amazing " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Clifford CA $154 CA $169 total includes taxes & fees Mar 30 - Mar 31 [](https://www.expedia.ca/Anderson-Hotels-Tru-By-Hilton-Seneca-Clemson.h34323330.Hotel-Information) ![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/128000000/127210000/127201800/127201761/ffe72826.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/128000000/127210000/127201800/127201761/267e5668.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/128000000/127210000/127201800/127201761/cbd32bc9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/128000000/127210000/127201800/127201761/934631cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Deluxe Inn [](https://www.expedia.ca/Mauldin-Hotels-Deluxe-Inn.h127201761.Hotel-Information) Mauldin CA $92 CA $102 total includes taxes & fees Mar 25 - Mar 26 [](https://www.expedia.ca/Mauldin-Hotels-Deluxe-Inn.h127201761.Hotel-Information) ![Golf](https://images.trvl-media.com/lodging/9000000/8480000/8475000/8474950/ad943919.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lunch, dinner, brunch served; American cuisine ](https://images.trvl-media.com/lodging/9000000/8480000/8475000/8474950/199642a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool, open 10:00 AM to 9:00 PM, free cabanas](https://images.trvl-media.com/lodging/9000000/8480000/8475000/8474950/8fa71ed7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/9000000/8480000/8475000/8474950/0aec11f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Clemson University's James F. Martin Inn [](https://www.expedia.ca/Anderson-Hotels-Clemson-Universitys-James-F-Martin-Inn.h8474950.Hotel-Information) Clemson 9.4/10 Exceptional (987 reviews) "Excellent stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elliott CA $204 CA $227 total includes taxes & fees Mar 25 - Mar 26 [](https://www.expedia.ca/Anderson-Hotels-Clemson-Universitys-James-F-Martin-Inn.h8474950.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/b0e15e12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Double Beds, Non Smoking | Living area](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/536a8160.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/w5755h3840x5y0-5e0099e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/8238721d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Embassy Suites Greenville Golf Resort & Conference Center [](https://www.expedia.ca/Greenville-Hotels-Embassy-Suites-Greenville-Golf-Resort-Conference-Center.h3223.Hotel-Information) Greenville 9.0/10 Wonderful (1,125 reviews) "Clean room and great Breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tara CA $134 CA $147 total includes taxes & fees Apr 5 - Apr 6 [](https://www.expedia.ca/Greenville-Hotels-Embassy-Suites-Greenville-Golf-Resort-Conference-Center.h3223.Hotel-Information) ![Front of property - evening/night](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/5971f25f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Gazebo](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/1fc30205.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Concierge desk](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/1d70fbe2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily local cuisine breakfast](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/9966f479.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd. [](https://www.expedia.ca/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Woodruff-Rd.h22513453.Hotel-Information) Greenville 8.8/10 Excellent (149 reviews) "Great place to stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Roymond CA $109 CA $123 total includes taxes & fees Apr 16 - Apr 17 [](https://www.expedia.ca/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Woodruff-Rd.h22513453.Hotel-Information) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/120000/119100/119074/5cc3b6ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/120000/119100/119074/51a7c4d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/120000/119100/119074/0d8d0617.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/120000/119100/119074/95c63f23.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Greenville Simpsonville [](https://www.expedia.ca/Simpsonville-Hotels-Fairfield-Inn-Suites-By-Marriott-Greenville-Simpsonville.h119074.Hotel-Information) Simpsonville 9.0/10 Wonderful (685 reviews) "Great location, great service, great facility " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) henry CA $121 CA $133 total includes taxes & fees Mar 29 - Mar 30 [](https://www.expedia.ca/Simpsonville-Hotels-Fairfield-Inn-Suites-By-Marriott-Greenville-Simpsonville.h119074.Hotel-Information) ![Aerial view](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/db449d90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/91e6d418.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/589bd84f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/ad742419.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lakeside Lodge Clemson [](https://www.expedia.ca/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information) Seneca 9.0/10 Wonderful (1,002 reviews) "Great place and location, great mattress, " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jeffrey CA $150 CA $186 total includes taxes & fees Apr 16 - Apr 17 [](https://www.expedia.ca/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information) ![Hallway](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/4d00561c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cafe](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/893b2bfc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception hall](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/959a330b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/cb83efe8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Inn at Patrick Square [](https://www.expedia.ca/Anderson-Hotels-The-Inn-At-Patrick-Square.h19511329.Hotel-Information) Clemson 9.8/10 Exceptional (813 reviews) "Staff were lovely and room was very clean. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lauren CA $218 CA $242 total includes taxes & fees Apr 16 - Apr 17 [](https://www.expedia.ca/Anderson-Hotels-The-Inn-At-Patrick-Square.h19511329.Hotel-Information) ![Free breakfast](https://images.trvl-media.com/lodging/2000000/1460000/1453500/1453465/353a96bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1460000/1453500/1453465/120fd9b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Two queen beds nonsmoking](https://images.trvl-media.com/lodging/2000000/1460000/1453500/1453465/e06b0f6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1460000/1453500/1453465/14b9a4cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Easley [](https://www.expedia.ca/Easley-Hotels-Hampton-Inn-Easley.h1453465.Hotel-Information) Easley 9.2/10 Wonderful (693 reviews) "Yes" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) connie CA $180 CA $200 total includes taxes & fees Apr 18 - Apr 19 [](https://www.expedia.ca/Easley-Hotels-Hampton-Inn-Easley.h1453465.Hotel-Information) ![Free daily full breakfast](https://images.trvl-media.com/lodging/1000000/30000/26900/26875/54b1a852.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/30000/26900/26875/95b4cb26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/26900/26875/7e082995.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, soundproofing, iron/ironing board](https://images.trvl-media.com/lodging/1000000/30000/26900/26875/ea1edcbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Clinton - Laurens I-26 [](https://www.expedia.ca/Clinton-Hotels-Quality-Inn-Clinton.h26875.Hotel-Information) Clinton 7.4/10 Good (538 reviews) "Very friendly staff and places to eat close by! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Burit CA $89 CA $105 total includes taxes & fees Mar 31 - Apr 1 [](https://www.expedia.ca/Clinton-Hotels-Quality-Inn-Clinton.h26875.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/850000/848800/848780/9bab6d34.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/850000/848800/848780/0c8d8851.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/850000/848800/848780/0160650e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/850000/848800/848780/227b33b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG [](https://www.expedia.ca/Anderson-Hotels-Holiday-Inn-Express-Hotel-Suites-Anderson-I-85.h848780.Hotel-Information) Anderson 9.0/10 Wonderful (600 reviews) "Clean rooms, friendly staff, great breakfast options!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lauren CA $141 CA $157 total includes taxes & fees Apr 5 - Apr 6 [](https://www.expedia.ca/Anderson-Hotels-Holiday-Inn-Express-Hotel-Suites-Anderson-I-85.h848780.Hotel-Information) ![Suite, 1 King Bed with Sofa bed, Non Smoking (Efficiency)](https://images.trvl-media.com/lodging/1000000/20000/19100/19019/60d71ae1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/19100/19019/26b1d839.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/19100/19019/4f8e319f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/19100/19019/3e3a13ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Clemson - University Area [](https://www.expedia.ca/Anderson-Hotels-Comfort-Inn-Suites-Clemson-University-Area.h19019.Hotel-Information) Clemson 8.2/10 Very good (1,007 reviews) "Easy check in / clean room / nice staff& good breakfast …well done " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) HANS CA $145 CA $161 total includes taxes & fees Apr 16 - Apr 17 [](https://www.expedia.ca/Anderson-Hotels-Comfort-Inn-Suites-Clemson-University-Area.h19019.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-04-07&endDate=2026-04-08®ionId=553248635975748552&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Vacation Rentals in Upstate South Carolina Cabin ![View from property](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/d7c06df6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, towels, soap, shampoo](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/cf119645.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin, 1 Queen Bed (View) | Private kitchen](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/60991646.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/53271cae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy [](https://www.expedia.ca/Seneca-Hotels-Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information) Seneca 9.8/10 Exceptional (66 reviews) "Excellent stay." [](https://www.expedia.ca/Seneca-Hotels-Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information) Cabin ![Premium bedding, in-room safe, individually furnished, laptop workspace](https://images.trvl-media.com/lodging/123000000/122100000/122099800/122099740/afe0f510.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin, 1 Bedroom, Courtyard View | Living area](https://images.trvl-media.com/lodging/123000000/122100000/122099800/122099740/3f2de599.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool, open 7:00 AM to 10:00 PM, pool umbrellas](https://images.trvl-media.com/lodging/123000000/122100000/122099800/122099740/b26b87ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin, 1 Bedroom, Courtyard View | Front of property](https://images.trvl-media.com/lodging/123000000/122100000/122099800/122099740/f825207a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Carolina Camp Cedar [](https://www.expedia.ca/Pickens-Hotels-Carolina-Camp-Cedar.h122099740.Hotel-Information) Pickens 10/10 Exceptional (3 reviews) "The cottage was clean, staff was so friendly, our stay was quiet and peaceful… it was perfect! Definitely planning to stay there again!" [](https://www.expedia.ca/Pickens-Hotels-Carolina-Camp-Cedar.h122099740.Hotel-Information) Cottage ![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/112000000/111930000/111929300/111929202/803858a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/112000000/111930000/111929300/111929202/5001142e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/112000000/111930000/111929300/111929202/db8f55c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/112000000/111930000/111929300/111929202/02c27678.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### < 3 Mi to Dtwn: Modern Cottage in Greenville! [](https://www.expedia.ca/Greenville-Hotels-3-Mi-To-Dtwn-Modern-Cottage-In-Greenville.h111929202.Hotel-Information) Greenville 10/10 Exceptional (1 review) [](https://www.expedia.ca/Greenville-Hotels-3-Mi-To-Dtwn-Modern-Cottage-In-Greenville.h111929202.Hotel-Information) Aparthotel ![Trailside Wedge Cottage | Terrace/patio](https://images.trvl-media.com/lodging/89000000/88370000/88362000/88361952/346fcb37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/89000000/88370000/88362000/88361952/87440d66.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Trailside Wedge Cottage | Terrace/patio](https://images.trvl-media.com/lodging/89000000/88370000/88362000/88361952/fa38c3ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Vista Wedge Cottage | Private kitchen](https://images.trvl-media.com/lodging/89000000/88370000/88362000/88361952/9304eefe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Station by Compo Hotels [](https://www.expedia.ca/Travelers-Rest-Hotels-The-Station-By-Compo-Hotels.h88361952.Hotel-Information) Travelers Rest 10/10 Exceptional (18 reviews) "great place perfect for more privacy vs. a standard hotel" [](https://www.expedia.ca/Travelers-Rest-Hotels-The-Station-By-Compo-Hotels.h88361952.Hotel-Information) Aparthotel ![Full-size fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/70000000/69720000/69716800/69716747/61217476.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/70000000/69720000/69716800/69716747/002ffe20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/70000000/69720000/69716800/69716747/2d11b158.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, individually furnished, desk, laptop workspace](https://images.trvl-media.com/lodging/70000000/69720000/69716800/69716747/464c71ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### stayAPT Suites Greenville-Haywood Mall [](https://www.expedia.ca/Greenville-Hotels-StayAPT-Suites-Greenville-Haywood-Mall.h69716747.Hotel-Information) Greenville 9.0/10 Wonderful (212 reviews) "Nice gym, good breakfast and the rooms are clean and well appointed. Good hotel stayed one night with my family " [](https://www.expedia.ca/Greenville-Hotels-StayAPT-Suites-Greenville-Haywood-Mall.h69716747.Hotel-Information) Cottage ![Signature Cottage, 2 Bedrooms | Living room](https://images.trvl-media.com/lodging/90000000/89510000/89502700/89502605/a4df93b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature Cottage, 2 Bedrooms | Private kitchen](https://images.trvl-media.com/lodging/90000000/89510000/89502700/89502605/w775h924x3y0-5b08ac43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature Cottage, 2 Bedrooms](https://images.trvl-media.com/lodging/90000000/89510000/89502700/89502605/9cd5859a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/90000000/89510000/89502700/89502605/b86441f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Clemson Memorabilia House [](https://www.expedia.ca/Clemson-Hotels-Clemson-Memorabilia-House.h89502605.Hotel-Information) Clemson 9.8/10 Exceptional (9 reviews) "We enjoyed our stay, it was the perfect size for our family of four. " [](https://www.expedia.ca/Clemson-Hotels-Clemson-Memorabilia-House.h89502605.Hotel-Information) Mobile Home ![Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining](https://images.trvl-media.com/lodging/10000000/9130000/9126600/9126575/e62d89db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room](https://images.trvl-media.com/lodging/10000000/9130000/9126600/9126575/6f5c7f95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | Living room](https://images.trvl-media.com/lodging/10000000/9130000/9126600/9126575/1853a44e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/10000000/9130000/9126600/9126575/dcda994e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Carolina Landing RV Resort - Caravan Park [](https://www.expedia.ca/Fair-Play-Hotels-Carolina-Landing-RV-Resort-Caravan-Park.h9126575.Hotel-Information) Fair Play 7.6/10 Good (47 reviews) "Lake " [](https://www.expedia.ca/Fair-Play-Hotels-Carolina-Landing-RV-Resort-Caravan-Park.h9126575.Hotel-Information) Apartment ![Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area](https://images.trvl-media.com/lodging/39000000/38600000/38593300/38593248/5e1376bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area](https://images.trvl-media.com/lodging/39000000/38600000/38593300/38593248/fb93f07a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Private kitchen](https://images.trvl-media.com/lodging/39000000/38600000/38593300/38593248/d192b91d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![One Bedroom (Self Check-in with Virtual Front Desk)](https://images.trvl-media.com/lodging/39000000/38600000/38593300/38593248/21618793.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Mint House Greenville Downtown by Kasa [](https://www.expedia.ca/Greenville-Spartanburg-Hotels-Mint-House-Downtown-Greenville.h38593248.Hotel-Information) Greenville Downtown 9.2/10 Wonderful (804 reviews) "Great location! It was clean, comfortable and quiet! " [](https://www.expedia.ca/Greenville-Spartanburg-Hotels-Mint-House-Downtown-Greenville.h38593248.Hotel-Information) Cottage ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/99000000/98550000/98548800/98548744/ce6330d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/99000000/98550000/98548800/98548744/f306db0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/99000000/98550000/98548800/98548744/1cbd1706.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/99000000/98550000/98548800/98548744/6f31060d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Updated Greenville Home w/ Backyard! [](https://www.expedia.ca/Greenville-Hotels-Updated-Greenville-Home-W-Backyard.h98548744.Hotel-Information) Greenville 10/10 Exceptional (2 reviews) [](https://www.expedia.ca/Greenville-Hotels-Updated-Greenville-Home-W-Backyard.h98548744.Hotel-Information) Cottage ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/104000000/103710000/103707900/103707807/784635bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/104000000/103710000/103707900/103707807/09b84ce7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/104000000/103710000/103707900/103707807/e4c6187d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/104000000/103710000/103707900/103707807/6c10521c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Waterfront Seneca Cabin \~ 4 Mi to Boat Launch! [](https://www.expedia.ca/Seneca-Hotels-Waterfront-Seneca-Cabin-4-Mi-To-Boat-Launch.h103707807.Hotel-Information) Seneca 10/10 Exceptional (1 review) "Beautiful and quaint cabin! Highly recommend, great view of the lake." [](https://www.expedia.ca/Seneca-Hotels-Waterfront-Seneca-Cabin-4-Mi-To-Boat-Launch.h103707807.Hotel-Information) Cottage ![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537500/93537410/d0930e15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537500/93537410/97641e90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537500/93537410/f05b75da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537500/93537410/ad3a4036.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Stunning Lakefront Retreat w/ Dock Access! [](https://www.expedia.ca/Greenwood-Hotels-Stunning-Lakefront-Retreat-W-Dock-Access.h93537410.Hotel-Information) Greenwood 10/10 Exceptional (1 review) [](https://www.expedia.ca/Greenwood-Hotels-Stunning-Lakefront-Retreat-W-Dock-Access.h93537410.Hotel-Information) Cottage ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/116000000/115590000/115584200/115584157/cbc428e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/116000000/115590000/115584200/115584157/f063ed32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/116000000/115590000/115584200/115584157/9bd47812.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/116000000/115590000/115584200/115584157/7bea9b1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Stay at Jos Taylor Retreat: 9 Mi to Greenville! [](https://www.expedia.ca/Taylors-Hotels-Stay-At-Jos-Taylor-Retreat-9-Mi-To-Greenville.h115584157.Hotel-Information) Taylors 10/10 Exceptional (1 review) "This rental is a time capsule that takes you back to Grandma and Grandpa's home. The owner is great to communicate with, as well as their property manager. Quaint older furniture, complete with blankets on the couches. There's all you need to cook and even a great cast-iron frying pan. I wish we had stayed here longer." [](https://www.expedia.ca/Taylors-Hotels-Stay-At-Jos-Taylor-Retreat-9-Mi-To-Greenville.h115584157.Hotel-Information) Cottage ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/120000000/119870000/119865300/119865212/83f2467b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/120000000/119870000/119865300/119865212/72e7e252.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/120000000/119870000/119865300/119865212/1cae0fc5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/120000000/119870000/119865300/119865212/9010a905.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 8 Mi to Clemson: Peaceful Family Home w/ Yard [](https://www.expedia.ca/Seneca-Hotels-8-Mi-To-Clemson-Peaceful-Family-Home-W-Yard.h119865212.Hotel-Information) Seneca 10/10 Exceptional (1 review) "The place was all out perfect the owner was polite and perfect. It was a very peaceful place to stay thank you so much." [](https://www.expedia.ca/Seneca-Hotels-8-Mi-To-Clemson-Peaceful-Family-Home-W-Yard.h119865212.Hotel-Information) Cottage ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/95000000/94960000/94956800/94956739/4dc43901.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/95000000/94960000/94956800/94956739/15dea704.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/95000000/94960000/94956800/94956739/0d9401a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/95000000/94960000/94956800/94956739/94a8ad64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Blue Ridge Mtn Cabin Near Hiking & Biking Trails! [](https://www.expedia.ca/Travelers-Rest-Hotels-Finns-Cabin-Blue-Ridge-Mountain-Retreat.h94956739.Hotel-Information) Travelers Rest 10/10 Exceptional (3 reviews) "Great place for the weekend " [](https://www.expedia.ca/Travelers-Rest-Hotels-Finns-Cabin-Blue-Ridge-Mountain-Retreat.h94956739.Hotel-Information) Cottage ![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/99000000/98560000/98551000/98550977/79219c5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/99000000/98560000/98551000/98550977/074e90eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/99000000/98560000/98551000/98550977/1de2cbd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/99000000/98560000/98551000/98550977/9b661a37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Greer Guest House < 1 Mi to Park & Downtown Area! [](https://www.expedia.ca/Greer-Hotels-Greer-Guest-House-1-Mi-To-Park-Downtown-Area.h98550977.Hotel-Information) Greer 10/10 Exceptional (2 reviews) "Nice place en Greenville area " [](https://www.expedia.ca/Greer-Hotels-Greer-Guest-House-1-Mi-To-Park-Downtown-Area.h98550977.Hotel-Information) [See all vacation rentals](https://expedia.ca/Hotel-Search?startDate=2026-04-21&endDate=2026-04-24®ionId=553248635975748552&adults=2&sort=RECOMMENDED&stay_options_group=vacation_rentals_option&categorySearch=vacation_rentals_option&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FUpstate-South-Carolina-Hotels.d553248635975748552.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FUpstate-South-Carolina-Hotels.d553248635975748552.Travel-Guide-Hotels) ## Stay near popular Southeastern United States attractions !["Clemson University is an American public, coeducational, land-grant and sea-grant research university located in Clemson, South Carolina, United States.More clemson images:"](https://images.trvl-media.com/place/6127431/81e51bd8-6dfc-4739-9fb0-b15a1329fa3d.jpg) ### Clemson University 4.7/5 (738 reviews) Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6127431) ![Exploring Falls Park on the Reedy in Downtown Greenville, South Carolina during a peaceful afternoon stroll with scenic views](https://images.trvl-media.com/place/6082697/4d276125-b8b6-4bd4-9887-c71157164970.jpg) ### Falls Park on the Reedy 4.7/5 (1,399 reviews) Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6082697) ![Nice little church with a beautiful Mountain view](https://images.trvl-media.com/place/553248621532656718/980f0b0b-1c20-45c2-a7ca-b2a7d56b195b.jpg) Photo by Pon Xayavong Photography ### Fred W. Symmes Chapel 4.8/5 (13 reviews) You can find out about the history of Cleveland when you stop by Fred W. Symmes Chapel. Wander the lakeside and forest in this relaxing area. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532656718) ### Bon Secours Wellness Arena 4.2/5 (601 reviews) Catch an event at Bon Secours Wellness Arena during your trip to Greenville. Stroll along the riverfront or experience the acclaimed theater scene in this family-friendly area. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6082715) ### Haywood Mall 4.3/5 (952 reviews) During your trip to Greenville, you can browse for the perfect souvenirs at Haywood Mall. Experience the great live music or attend a sporting event in this family-friendly area. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6130785) ### Memorial Stadium 4.7/5 (201 reviews) Catch an event at Memorial Stadium during your trip to Clemson. Experience the area's theater scene or attend a football game. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6193935) ### BMW Performance Center 4.7/5 (50 reviews) You can spend an afternoon browsing the exhibits at BMW Performance Center during your travels in Greer. While in this family-friendly area, you can savor the charming coffeehouses. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6217409) ## Learn more about Upstate South Carolina Venture to sights like Heritage Park and Conestee Nature Preserve as you discover Upstate South Carolina. [See all hotels in Upstate South Carolina](https://www.expedia.ca/Hotel-Search?startDate=2026-04-07&endDate=2026-04-08&adults=2®ionId=553248635975748552) ![It is only a 1 mile hike to this beauty. View a video about it here: https://www.hdcarolina.com/episode/riley-moore-falls #Waterfall](https://images.trvl-media.com/place/6122927/69b8ebaa-53a3-428e-ba53-37ac2de11862.jpg?impolicy=fcrop&w=900&h=600&p=1&q=high) Photo by Ryan Watts ## Top Upstate South Carolina Hotel Reviews ## Recent Reviews in Upstate South Carolina ![Hyatt Regency Greenville](https://images.trvl-media.com/lodging/1000000/30000/22300/22252/2e6ff142_y.jpg) ### Hyatt Regency Greenville 10/10 Excellent "Check in was easy. Front desk staff was very friendly." [](https://expedia.ca/Greenville-Hotels-Hyatt-Regency-Greenville.h22252.Hotel-Information) ![Hilton Greenville](https://images.trvl-media.com/lodging/1000000/30000/23200/23172/8017eeff_y.jpg) ### Hilton Greenville 4/10 Poor "The full-suite king bed was rock hard, the air conditioner from the adjoining suite vibrated the wall periodically throughout the night, and the elevator machinery hummed all night. No more Hilton. " [](https://expedia.ca/Greenville-Hotels-Hilton-Greenville.h23172.Hotel-Information) ![Comfort Inn Greenville - Haywood Mall](https://images.trvl-media.com/lodging/1000000/30000/25000/24994/840ecd1b_y.jpg) ### Comfort Inn Greenville - Haywood Mall 6/10 Okay "Checked in and the female associate was very professional. The female who we were checked out by seemed to not be having a very good day. When we told her the A/C didn’t Really cool the room the reaction was “Well in the future you should let the person on duty at night. " [](https://expedia.ca/Greenville-Hotels-Comfort-Inn-Greenville-Haywood-Mall.h24994.Hotel-Information) ![Mint House Greenville Downtown by Kasa](https://images.trvl-media.com/lodging/39000000/38600000/38593300/38593248/5e1376bb_y.jpg) ### Mint House Greenville Downtown by Kasa 8/10 Good "The coffee machine did not work. Also, for those traveling with family/children it should noted only one TV is available for the property (no tv in the bedrooms)." [](https://expedia.ca/Greenville-Spartanburg-Hotels-Mint-House-Downtown-Greenville.h38593248.Hotel-Information) ![Best Western Plus Greenville I-385 Inn & Suites](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/f09ffe86_y.jpg) ### Best Western Plus Greenville I-385 Inn & Suites 10/10 Excellent "Nice friendly staff, clean rooms, very efficient! Will use this location again!" [](https://expedia.ca/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) ![Drury Inn & Suites Greenville](https://images.trvl-media.com/lodging/2000000/1540000/1533500/1533439/6d7853ae_y.jpg) ### Drury Inn & Suites Greenville 10/10 Excellent "Everything was great" [](https://expedia.ca/Greenville-Hotels-Drury-Inn-Suites-Greenville.h1533439.Hotel-Information) ![Embassy Suites Greenville Golf Resort & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/b0e15e12_y.jpg) ### Embassy Suites Greenville Golf Resort & Conference Center 10/10 Excellent "Nice" [](https://expedia.ca/Greenville-Hotels-Embassy-Suites-Greenville-Golf-Resort-Conference-Center.h3223.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/5971f25f_y.jpg) ### La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd. 6/10 Okay "Property as great. Room was clean. You have got to do something about how hard the doors shut and how much noise is made. You can hear anyone on your floor going in and out at any hour. " [](https://expedia.ca/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Woodruff-Rd.h22513453.Hotel-Information) ![Hyatt Place Greenville/Haywood](https://images.trvl-media.com/lodging/1000000/70000/64600/64570/w3840h2556x0y3-09ad394d_y.jpg) ### Hyatt Place Greenville/Haywood 8/10 Good "Great location for what we needed. Rooms were smaller than we imagined. Very clean, great staff." [](https://expedia.ca/Greenville-Hotels-Hyatt-Place-GreenvilleHaywood.h64570.Hotel-Information) ## More cheap stays in Upstate South Carolina ![Urban Boutique Hotel, BW Signature Collection](https://images.trvl-media.com/lodging/1000000/30000/24400/24334/f974826b_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Urban Boutique Hotel, BW Signature Collection 536 Wade Hampton Blvd Greenville SC CA $89 CA $97 total Apr 12 - Apr 13 includes taxes & fees 8/10 Very Good! (979 reviews) [](https://expedia.ca/Greenville-Hotels-Urban-Boutique-Hotel.h24334.Hotel-Information) ![Best Western Greenville Airport Inn](https://images.trvl-media.com/lodging/1000000/10000/800/708/w2678h1966x0y0-e3e18b8e_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Best Western Greenville Airport Inn 5009 Pelham Road Greenville SC CA $99 CA $109 total Apr 16 - Apr 17 includes taxes & fees 7.8/10 Good! (1,006 reviews) [](https://expedia.ca/Greenville-Hotels-Best-Western-Greenville-Airport-Inn.h708.Hotel-Information) ![Comfort Inn Greenville - Haywood Mall](https://images.trvl-media.com/lodging/1000000/30000/25000/24994/840ecd1b_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Comfort Inn Greenville - Haywood Mall 246 Congaree Road Greenville SC CA $104 CA $119 total Apr 5 - Apr 6 includes taxes & fees 8/10 Very Good! (1,004 reviews) [](https://expedia.ca/Greenville-Hotels-Comfort-Inn-Greenville-Haywood-Mall.h24994.Hotel-Information) ![Best Western Plus Greenville I-385 Inn & Suites](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/f09ffe86_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Best Western Plus Greenville I-385 Inn & Suites 831 Congaree Rd Greenville SC CA $116 CA $128 total Apr 5 - Apr 6 includes taxes & fees 9.2/10 Wonderful! (1,444 reviews) [](https://expedia.ca/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) ![Comfort Suites Greenville Airport](https://images.trvl-media.com/lodging/47000000/46120000/46116400/46116309/76f56d99_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Comfort Suites Greenville Airport 1371 Garlington Road Greenville SC CA $135 CA $153 total Apr 19 - Apr 20 includes taxes & fees 9.2/10 Wonderful! (1,007 reviews) [](https://expedia.ca/Greenville-Spartanburg-Hotels-Comfort-Suites.h46116309.Hotel-Information) ![Best Western Plus Clemson Hotel & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/1400/1370/w3837h2558x3y3-4efd29d6_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Best Western Plus Clemson Hotel & Conference Center 1310 Tiger Blvd Clemson SC CA $142 CA $158 total Apr 3 - Apr 4 includes taxes & fees 8.2/10 Very Good! (1,002 reviews) [](https://expedia.ca/Anderson-Hotels-Best-Western-Plus-University-Inn-Conference-Center.h1370.Hotel-Information) ## Hotels in Upstate South Carolina with star rating ![4 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/23700/23677/6ae928dd_z.jpg) 4 Star Hotels 40 properties [](https://expedia.ca/4Star-Upstate-South-Carolina-Hotels.s40-0-d553248635975748552.Travel-Guide-Filter-Hotels) ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 215 properties [](https://expedia.ca/3Star-Upstate-South-Carolina-Hotels.s30-0-d553248635975748552.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 145 properties [](https://expedia.ca/2Star-Upstate-South-Carolina-Hotels.s20-0-d553248635975748552.Travel-Guide-Filter-Hotels) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - 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